The four regional group champions played off over two legs for two of the promotion spots. Second leg matches were as follows, with Sabadell and Murcia promoted and Eibar and Lugo entering the second phase of the play-offs. (29.05.11)
28 May | Eibar Lanzarote |
1-1 | Sabadell Marc Fernández |
29 May | Lugo Tornero |
1-0 | Murcia |
The remaining twelve teams who finished in the top four of the regional groups entered a knock-out stage, with the winners of the six games entering a second round together with the two losers of the above two ties (teams qualifying in bold). (29.05.11)
28 May | Sevilla B Deivid, Luis Alberto, Morales |
3-0 | Real Unión |
29 May | Badalona Vázquez |
1-0 | Leganés |
29 May | Mirandés Alain (2), Baquero (OG), Mújika |
4-1 | Cádiz Pachón |
29 May | Guadalajara Javi Soria |
1-1 | Orihuela Garavano |
29 May | Alcoyano Paco Esteban (2) |
2-2 | Real Madrid B Morata, Fran Rico |
29 May | Alavés Oscar Martínez |
1-0 | Melilla |
The four sides who finished fifth from bottom in the regional groups played-off to avoid the remaining two relegation spots. Caudal and Benidorm go down. (29.05.11)
29 May | Caudal Carlos Alvarez, José Luis |
2-1 (aet) | Conquense Belencoso |
29 May | Betis B Carlos Fernández (2), Bernal |
3-1 | Benidorm Luis |